Objectives : To assess the adequacy of initial standard dose of 100 ml of polyvalent anti-snake venom (ASV) and subsequent doses of 50 ml in correcting coagulation dysfunction in cases of viperine bite and to find the incidence of recurrence of coagulation dysfunction. The immunising venom used is common brown snake venom. High-dose anti-snake venom versus low-dose anti-snake venom in the treatment of poisonous snake bites – … It is a biological product that typically consists of venom neutralizing antibodies derived from a host animal, such as a horse or sheep. Dose and frequency of anti-snake venom injection in treatment of Echis carinatus (saw-scaled viper) bite. Information about the snakes covered by this antivenom . The administration of adrenaline and hydrocortisone may be repeated if necessary. Vijeth SR, Dutta TK, Shahapurkar J, Sahai A. extremity. It is made from horse IgG. The immunising venom used is common brown snake venom. Anti-snake venom (ASV) is the main treatment. 1004, 2017 WHO Expert Committee on Biological StandardizationSixty-seventh report 9. In India, polyvalent ASV, i.e. If no reaction occurs after 0.5ml of undiluted Anti Snake Venom Antiserum has been administered, switch over to the intramuscular route and continue doubling the dose at 15 minutes intervals until the entire dose … Adverse reactions Antivenom being derived from equines is heterologous to human can give either early or late reaction. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. this retrospective study was conducted on the 154 patients (mean age ± sd, range) of viper snake bites who were referred to the emergency ward of razi hospital, ahvaz, iran over 2 years period (2004 - 2006). The fangs are small; average fang length in adults is only 2.8mm. Anti-snake venom serum is administered intravenously either undiluted at the rate of 1ml. 198 WHO Technical Report Series, No. the administration of Snake Venom Antiserum subsequent to bite. Wait for at least 30 minutes before injecting another dose. Antivenoms can prevent or reverse most of the snakebite envenomings effects, and play a crucial role in minimizing mortality and morbidity. the administration of Snake Venom Antiserum subsequent to bite. Return to start of page. The species. Average volume per ampoule is 4.5-9mL. ... Side Effects, Interactions, and Dosage … S nake bite remains a significant cause of morbidity and mortality, particularly in the rural occupational sector. OBJECTIVES: To assess the adequacy of initial standard dose of 100 ml of polyvalent anti-snake venom (ASV) and subsequent doses of 50 ml in correcting coagulation dysfunction in cases of viperine bite and to find the incidence of recurrence of coagulation … * Not commercially available in the U.S. † Not commercially available in Canada. Wait for at least 30 minutes before injecting another dose. this study was done to determine whether high or low dose of anti-snake venom (asv) is better in coagulopathy in victims of envenoming by vipers. Adrenaline should be always kept handy, before starting the dose of Snake venom antiserum. In children and small adults (body weight less than 40kg) up to 50% greater doses of anti snake venom serum should be administered to neutralize the relatively higher venom concentration. sea snake antivenom {01} {15}. Paul V, Pratibha S, Prahlad KA, et al. If no reaction occurs after 0.5ml of undiluted Anti Snake Venom Antiserum has been administered, switch over to the intramuscular route and continue doubling the dose at 15 minutes intervals until the entire dose … Therefore, diphenhydramine has no role in its management. In children and small adults (body weight less than 40kg) up to 50% greater doses of anti snake venom serum should be administered to neutralize the relatively higher venom concentration. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Drug interactions There are no known drug interactions reported. Each ampoule contains 1000 units of neutralising capacity against the target venoms. Anti-H1 histamines blockers and corticosteroids have proved ineffective, singly or in combination, in preventing early anaphylactic antivenom reactions, but in a recent, powerful study, epinephrine (adult dose 0.25 ml of 0.1% solution) administered subcutaneously before antivenom was given reduced the frequency of severe early anaphylactic reactions [12].